Muscle Relaxant Analgesics & NSAIDs

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• Eliminates all types of pain & inflammatory conditions with anti-pyretic action.
• Relieve pain, tenderness, swelling and stiffness caused by osteoarthritis.
• Eases mild to moderate pain, especially that associated with menstruation
• Fast onset of action in migraine than with oral sumatriptan or ergotamine plus caffeine, with favourable inhibitory effects on accompanying symptoms such as nausea & vomitting.

• 1 tablet daily, may be increased to BID depending on risk & benefit ratio

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• Metaxalone suppersses the polysynaptic spinal cord reflexes, while leaving the monosynaptic sensorimotor pathway intact
• Edge over other skeletal muscule relaxants which include reduced sedation, lack of abuse potential & limited accumulation of the drug because of its short elimination half life

• Shows highest inhibition of prostaglandins among other NSAIDs thus ensures potent relief
• Diclofenac has greater cox-2 selectivity than ibuprofen & naproxen, thus show potent analgesic effect with lesser side effect

• 1 Tablet BID-TDS daily

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• Aceclofenac has rapid onset & longer duration of action compared to Diclofenac and shows tolerability profile superior to diclofenac.
• In multiple sclerosis or cerebrovascular lesions, Muscle strength improvement is greater with tizanidine than baclofen & .
• The combination (Aceclofenac 100mg Tizanidine 2mg) shows a trend towards superiority in its efficacy and tolerability compared with monotherapy in low back pain.
• Tizanidine, when coadministered with an NSAID, has a synergistic effect in terms of efficacy and some protective effect against the GI adverse events caused by NSAIDs.

• 1 Tablet twice daily

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• It Reduces contractions of the muscles in the intestines
• Effectively treats different bowel problems including diarrhea-predominat irritable bowel syndrome
• Decreases intestinal cramping, providing muscle relaxation

• Provides short term treatment of mild to moderated painful spasm
• Reduces pain and excessive blood loss in menorrhagia due to ovulatory dysfunctional.

• Ensures prompt relief from inflammatory conditions

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• Mefenamic acid performs superior than aspirin, dextropropoxyphene plus paracetamol and indomethacin in lower back pain.
• Tizanidine, when co-administered with an NSAID, has a synergistic effectin terms of efficacy and some protective effect against the GI adverse events caused by Nsaids.
• Muscle tone, global tolerability and muscle weakness favors use tizanidine over Baclofen

• 1 Tablet twice a day

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• Shows superior activity(60%) than piroxicam (49%) in treatmentpf soft tissue injury
• Effectively attenuates night time dysmenorrheic pain & restores measure of sleep quality
• Significantly reduce roal temperature & throat pain associated with benign acute febrile sore throat when compared wtih paracetamol

• An effective proteolytic enzyme that manages trauma & fastens wound healing by 50%

• 1 tablet 2-3 times daily

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• Etodolac 300 Mg & Thiocolchicoside 4 Mg

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• Combination of Bromelain, trypsin & Rutoside results in significant & similar reduction in pain, inflammation and joint stiffness as that with diclofenac in osteoarthritis of the knee and osteoarthritis of
• Alternative Medicine Review VOlume15,Number4
• More effective than NSAIDs in the treatment of activated, inflammatory degenerative spinal and join diseases,fibromyalgias & other rheumatic soft tissue diseases and has lesser side effects then NSAIDs.
• Effective in patientss with lateral ankle joint distortiosn.

• 2 Tablet thrice daily (with plenty of water)

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• Lornoxicam is more effective than diclofenac in early period in in renal colicky pain.
• Anti-inflammatory and antipyretic effcects of lornoxicam include prevention of the degenerative bone loss seen in chronic inflammation.
• Combination of Paracetamol and an NSAID offers superior analgesia compared with either drug alone.

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• More effective than celecoxib (400 mg) in reducing pain associated with arthroscopic anterior cruciate ligament reconstruction
• Highly effective than as analgesic after elective hallux valgus surgery
• An effective COX 2 inhibitor more beneficial than diclofenac in reducing pain associated with arthritis & ankylosing spondylitis
• Shows more rapid & prolonged relief than diclofenac sodium (50mg/BID) in post extraction dental pain
• Shows better pain relief, less menstrual blood loss & fewer side effects as compared to mefenamic acid (500mg/TDS) dysmenorrhea

• Once daily

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• Thiocolchicoside significantly suppressed osteoclastogenesis thus drug used to treat muscle pain, may also be considered as a new treatment for bone loss.
• Aceclofenac is better tolerated in terms of incidence and severity of GI adverse events & gastroprotective agents requirement than diclofenac.
• Thiocolchicoside scores significantly better over Tizanidine in the patients with accompanying muscle spasm, while it appears devoid of any effect in contrast to Tizanidine.

• One Tablet Twice Daily

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